The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis

Postpartum metritis in mares is a life-threatening condition associated with severe clinical signs due to endotoxemia, and it often followed by complications such as laminitis. Repeated large-volume uterine lavages are commonly recommended part of the treatment protocol remove endotoxin-laden contents from uterus. It has, however, also been suggested that may increase uptake endotoxin into circulation, leading deterioration signs. Endotoxemia release multitude inflammatory mediators regulating immune response. The aim this study was evaluate if lavage influences serum levels inflammation markers soluble CD14 (sCD14), chemokine (C-C motif) ligand 2 (CCL2), interleukin (IL)-10 postpartum metritis. Serum samples were collected eight treated for at university teaching hospital. Mares fever, tachycardia, and/or leukopenia hemosanguineous or purulent intrauterine fluid within 1 week foaling included study. taken before 15 30 minutes after starting lavage. concentrations sCD14, CCL2, IL-10 determined fluorescent bead–based immunoassay. There no significant differences between different sampling times. Heart rate significantly lower than before. body temperature leukocyte count not significant. In conclusion, had immediate effect on concentration IL-10, nor did affect parameters negatively.